Jeu. 12/07/2018 14:00 Amphi Jean Jacques Moreau, Bâtiment 2, RdC
ALLENA Rachele (Institut de Biomécanique Humaine Georges Charpak)
From cell to bone: interactions with the mechanical environment
When a prosthesis is implanted, the cortical bone around the implant starts to remodel in order to ensure the transfer of stresses between the bone and the prosthesis. In the literature, most of the existing models are able to describe the evolution of bone density through macroscale parameters, for instance the maximum principal stresses. Such a macroscale approach is necessary and useful for clinical applications. Nonetheless, we are interested in exploring and quantify the mechanical processes at the cell scale that initiate the remodeling process in order to fully understand the mechanobiological phenomenon. On one hand it is important to study the different cellular activities such as migration, proliferation and differentiation. Here, we will present some numerical models that has allowed to investigate single and collective cell migration and the influence of specific mechanical parameters like the rigidity and the morphology of the environment, the adhesion forces between the cell and the environment or the transmission of the forces between the cells. On the other hand, we hypothesize that microcracks initiate the remodeling process. Thus, we have developed a macroscale anisotropic damage model able to take into account the evolution of the microcracks field.
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